DegronMD

Uniprot ID: Q9Y6A5

Source protein: Transforming acidic coiled-coil-containing protein 3

Source gene: TACC3

Class: DEG_SCF_FBW7_2

Location: 195:200

E3 ligase: FBXW7

DEGRON score: 0.9984

ASA_SCORE: 79.4167

COIL: 0.8872

CONS_SCORE: 0.3106

DSS_SCORE: 0.6057

HELIX: 0.0607

FCONS_SCORE: 1.0157

RIG_SCORE: 0.6691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S210F	TCGA-AP-A059	UCEC	TCGA	VTPASE	DEG_SCF_FBW7_2	0.0556
p.S210F	TCGA-D9-A3Z1	SKCM	TCGA	VTPASE	DEG_SCF_FBW7_2	0.0556
p.S210F	DO38105	SKCM	ICGC	VTPASE	DEG_SCF_FBW7_2	0.0556
p.S210F	DO41361	UCEC	ICGC	VTPASE	DEG_SCF_FBW7_2	0.0556
p.S199F	SIDM01951	Colorectal Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	0.6871
p.R193K	SIDM00367	Small Cell Lung Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	0.2778
p.R193K	SIDM01574	Plasma Cell Myeloma	GDSC	VTPASE	DEG_SCF_FBW7_2	0.2778
p.R193K	ACH-000588	Myeloma	CCLE	VTPASE	DEG_SCF_FBW7_2	0.2778
p.R193K	ACH-002197	Lung Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.2778
p.S190F	SIDM00795	Melanoma	GDSC	VTPASE	DEG_SCF_FBW7_2	0.1944
p.S190F	ACH-000219	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.1944
p.S190F	ACH-002001	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.1944
p.S190F	ACH-002002	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.1944
p.S190F	ACH-002003	Skin Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.1944
p.S190F	A375	skin	COSMIC	VTPASE	DEG_SCF_FBW7_2	0.1944
p.D192N	SIDM00442	Thyroid Gland Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	0.25
p.D192N	ACH-000058	Thyroid Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.25
p.D192N	ML-1	thyroid	COSMIC	VTPASE	DEG_SCF_FBW7_2	0.25
p.V195M	SIDM01660	Kidney Carcinoma	GDSC	VTPASE	DEG_SCF_FBW7_2	0.6097
p.V195M	ACH-000709	Kidney Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.6097
p.V195M	ACH-001184	Sarcoma	CCLE	VTPASE	DEG_SCF_FBW7_2	0.6097
p.E200K	ACH-001283	Bone Cancer	CCLE	VTPASE	DEG_SCF_FBW7_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6A5	Transforming acidic coiled-coil-containing protein 3	DEG_SCF_FBW7_2	195:200	VTPASE	FBXW7	0.9984	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons