DegronMD

Uniprot ID: Q9Y6A5

Source protein: Transforming acidic coiled-coil-containing protein 3

Source gene: TACC3

Class: DEG_APCC_KENBOX_2

Location: 40:44

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9939

ASA_SCORE: 112.66

COIL: 0.9028

CONS_SCORE: 0.5148

DSS_SCORE: 0.528

HELIX: 0.0752

FCONS_SCORE: 1.1339

RIG_SCORE: 0.6974

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S33L	TCGA-A5-A0G2	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.1389
p.S33L	DO41235	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.1389
p.V44L	TCGA-B7-5816	STAD	TCGA	QKENV	DEG_APCC_KENBOX_2	0.5654
p.V44L	DO38599	STAD	ICGC	QKENV	DEG_APCC_KENBOX_2	0.5654
p.R37C	TCGA-CM-6162	COAD	TCGA	QKENV	DEG_APCC_KENBOX_2	0.25
p.R37C	DO8479	COAD	ICGC	QKENV	DEG_APCC_KENBOX_2	0.25
p.R37C	SIDM00451	T-Lymphoblastic Leukemia	GDSC	QKENV	DEG_APCC_KENBOX_2	0.25
p.R37C	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	QKENV	DEG_APCC_KENBOX_2	0.25
p.L36I	TCGA-EO-A3AY	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.2222
p.L36I	DO46853	RECA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.2222
p.L36I	DO43202	UCEC	ICGC	QKENV	DEG_APCC_KENBOX_2	0.2222
p.S39P	DO7102	CLLE	ICGC	QKENV	DEG_APCC_KENBOX_2	0.75
p.G31R	DO233156	GACA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.0833
p.M53V	DO23551	LIRI	ICGC	QKENV	DEG_APCC_KENBOX_2	0.0833
p.R37G	SIDM00664	Pancreatic Carcinoma	GDSC	QKENV	DEG_APCC_KENBOX_2	0.25
p.R37G	ACH-000178	Pancreatic Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	0.25
p.R37G	Hs766T	pancreas	COSMIC	QKENV	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_APCC_KENBOX_2	533:537	QKENV	APC,CDC20,FZR1	0.9267	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	253:257	QKENV	APC,CDC20,FZR1	0.8632	More...
Q9UHB6	LIM domain and actin-binding protein 1	DEG_APCC_KENBOX_2	305:309	QKENV	APC,CDC20,FZR1	0.9766	More...
Q9Y6A5	Transforming acidic coiled-coil-containing protein 3	DEG_APCC_KENBOX_2	40:44	QKENV	APC,CDC20,FZR1	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons