DegronMD - Q9UHB6(LIMA1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E307V	TCGA-86-7711	LUAD	TCGA	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.7693
p.E304G	TCGA-A4-A7UZ	KIRP	TCGA	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.3056
p.E297K	TCGA-AN-A046	BRCA	TCGA	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1111
p.E297K	SIDM00225	Melanoma	GDSC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1111
p.E297K	SIDM01546	Kidney Carcinoma	GDSC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1111
p.E297K	ACH-000234	Kidney Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1111
p.E297K	ACH-002143	Skin Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1111
p.E297K	IST-MEL1	skin	COSMIC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1111
p.E307D	TCGA-B5-A1MR	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.6758
p.E297G	TCGA-CR-7370	HNSC	TCGA	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1111
p.I298T	TCGA-CV-7248	HNSC	TCGA	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1389
p.S298F	DO51908	BLCA	ICGC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.1389
p.Q295E	DO23672	LUAD	ICGC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.0556
p.V305M	DO38202	STAD	ICGC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.7208
p.P313H	SIDM00789	Colorectal Carcinoma	GDSC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222
p.P313H	ACH-000997	Colon/Colorectal Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222
p.P313H	ACH-001061	Colon/Colorectal Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222
p.P313H	HCT-15	large intestine	COSMIC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation rewiring degron network	0.2222
p.S307P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.6752
p.S306P	GR-ST	haematopoietic and lymphoid tissue	COSMIC	QKENV	DEG_APCC_KENBOX_2	305:309	Mutation altering degron motif	0.6752

Kaplan plot for LIMA1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIMA1

UniProt ID: Q9UHB6

Entrez ID: 51474

Protein name: LIM domain and actin-binding protein 1 (Epithelial protein lost in neoplasm)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIMA1 in