DegronMD

Uniprot ID: Q9UHB6

Source protein: LIM domain and actin-binding protein 1

Source gene: LIMA1

Class: DEG_APCC_KENBOX_2

Location: 305:309

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9766

ASA_SCORE: 119.74

COIL: 0.8448

CONS_SCORE: 0.4403

DSS_SCORE: 0.5641

HELIX: 0.081

FCONS_SCORE: 1.0865

RIG_SCORE: 0.6599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E307V	TCGA-86-7711	LUAD	TCGA	QKENV	DEG_APCC_KENBOX_2	0.7693
p.E304G	TCGA-A4-A7UZ	KIRP	TCGA	QKENV	DEG_APCC_KENBOX_2	0.3056
p.E297K	TCGA-AN-A046	BRCA	TCGA	QKENV	DEG_APCC_KENBOX_2	0.1111
p.E297K	SIDM00225	Melanoma	GDSC	QKENV	DEG_APCC_KENBOX_2	0.1111
p.E297K	SIDM01546	Kidney Carcinoma	GDSC	QKENV	DEG_APCC_KENBOX_2	0.1111
p.E297K	ACH-000234	Kidney Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	0.1111
p.E297K	ACH-002143	Skin Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	0.1111
p.E297K	IST-MEL1	skin	COSMIC	QKENV	DEG_APCC_KENBOX_2	0.1111
p.E307D	TCGA-B5-A1MR	UCEC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.6758
p.E297G	TCGA-CR-7370	HNSC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.1111
p.I298T	TCGA-CV-7248	HNSC	TCGA	QKENV	DEG_APCC_KENBOX_2	0.1389
p.S298F	DO51908	BLCA	ICGC	QKENV	DEG_APCC_KENBOX_2	0.1389
p.Q295E	DO23672	LUAD	ICGC	QKENV	DEG_APCC_KENBOX_2	0.0556
p.V305M	DO38202	STAD	ICGC	QKENV	DEG_APCC_KENBOX_2	0.7208
p.P313H	SIDM00789	Colorectal Carcinoma	GDSC	QKENV	DEG_APCC_KENBOX_2	0.2222
p.P313H	ACH-000997	Colon/Colorectal Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	0.2222
p.P313H	ACH-001061	Colon/Colorectal Cancer	CCLE	QKENV	DEG_APCC_KENBOX_2	0.2222
p.P313H	HCT-15	large_intestine	COSMIC	QKENV	DEG_APCC_KENBOX_2	0.2222
p.S307P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	QKENV	DEG_APCC_KENBOX_2	0.6752
p.S306P	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	QKENV	DEG_APCC_KENBOX_2	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P10243	Myb-related protein A	DEG_APCC_KENBOX_2	533:537	QKENV	APC,CDC20,FZR1	0.9267	More...
P46013	Proliferation marker protein Ki-67	DEG_APCC_KENBOX_2	253:257	QKENV	APC,CDC20,FZR1	0.8632	More...
Q9UHB6	LIM domain and actin-binding protein 1	DEG_APCC_KENBOX_2	305:309	QKENV	APC,CDC20,FZR1	0.9766	More...
Q9Y6A5	Transforming acidic coiled-coil-containing protein 3	DEG_APCC_KENBOX_2	40:44	QKENV	APC,CDC20,FZR1	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons