DegronMD

Uniprot ID: Q9P2D1

Source protein: Chromodomain-helicase-DNA-binding protein 7

Source gene: CHD7

Class: DEG_SCF_FBW7_1

Location: 727:734

E3 ligase: FBXW7

DEGRON score: 0.995

ASA_SCORE: 103.15

COIL: 0.9516

CONS_SCORE: 0.3749

DSS_SCORE: 0.8922

HELIX: 0.0438

FCONS_SCORE: 1.19

RIG_SCORE: 0.4928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N724K	TCGA-CR-7380	HNSC	TCGA	LDKTPPPS	DEG_SCF_FBW7_1	0.25
p.N724K	DO14734	HNSC	ICGC	LDKTPPPS	DEG_SCF_FBW7_1	0.25
p.E741K	TCGA-LP-A5U2	CESC	TCGA	LDKTPPPS	DEG_SCF_FBW7_1	0.1389
p.E741K	DO51610	CESC	ICGC	LDKTPPPS	DEG_SCF_FBW7_1	0.1389
p.P733S	DO229502	SKCA	ICGC	LDKTPPPS	DEG_SCF_FBW7_1	0.5641
p.T730I	SIDM00232	Kidney Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	0.8189
p.T730I	ACH-002168	Kidney Cancer	CCLE	LDKTPPPS	DEG_SCF_FBW7_1	0.8189
p.T730I	NCC021	kidney	COSMIC	LDKTPPPS	DEG_SCF_FBW7_1	0.8189
p.G744S	SIDM00393	Gastric Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	0.0556
p.G744S	SIDM00032	Bladder Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	0.0556
p.G744S	SIDM01173	Rhabdomyosarcoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	0.0556
p.D728H	SIDM00183	Small Cell Lung Carcinoma	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	0.6577
p.D728H	SIDM01648	Non-Cancerous	GDSC	LDKTPPPS	DEG_SCF_FBW7_1	0.6577
p.D728H	ACH-002356	Non-Cancerous	CCLE	LDKTPPPS	DEG_SCF_FBW7_1	0.6577

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SCF_FBW7_1	727:734	LDKTPPPS	FBXW7	0.995	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons