DegronMD

Uniprot ID: Q9P2D1

Source protein: Chromodomain-helicase-DNA-binding protein 7

Source gene: CHD7

Class: DEG_SPOP_SBC_1

Location: 1904:1908

E3 ligase: SPOP

DEGRON score: 0.8978

ASA_SCORE: 66.18

COIL: 0.7758

CONS_SCORE: 0.4601

DSS_SCORE: 0.3645

HELIX: 0.1912

FCONS_SCORE: 1.0744

RIG_SCORE: 0.7899

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1909M	TCGA-AJ-A2QO	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	0.3056
p.L1909M	TCGA-CN-6988	HNSC	TCGA	PNTST	DEG_SPOP_SBC_1	0.3056
p.L1909M	DO14208	HNSC	ICGC	PNTST	DEG_SPOP_SBC_1	0.3056
p.L1909M	DO42177	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	0.3056
p.R1914H	TCGA-AP-A0LM	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	0.1667
p.R1914H	TCGA-BR-6452	STAD	TCGA	PNTST	DEG_SPOP_SBC_1	0.1667
p.R1914H	DO38404	STAD	ICGC	PNTST	DEG_SPOP_SBC_1	0.1667
p.R1914H	DO43306	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	0.1667
p.R1912C	TCGA-AX-A1CE	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	0.2222
p.R1912C	DO42280	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	0.2222
p.R1914C	TCGA-D1-A16F	UCEC	TCGA	PNTST	DEG_SPOP_SBC_1	0.1667
p.R1914C	DO42408	UCEC	ICGC	PNTST	DEG_SPOP_SBC_1	0.1667
p.S1907L	TCGA-EB-A4XL	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	0.7667
p.S1907L	DO47401	SKCM	ICGC	PNTST	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	565:569	PNTST	SPOP	0.5677	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12823:12827	PNTST	SPOP	0.6675	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	1904:1908	PNTST	SPOP	0.8978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons