DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12823:12827

E3 ligase: SPOP

DEGRON score: 0.6675

ASA_SCORE: 85.78

COIL: 0.918

CONS_SCORE: 0

DSS_SCORE: 0.6082

HELIX: 0.0198

FCONS_SCORE: 0

RIG_SCORE: 0.5957

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T12837A	TCGA-4W-AA9R	GBM	TCGA	PNTST	DEG_SPOP_SBC_1	0.0556
p.T12837A	DO219107	GBM	ICGC	PNTST	DEG_SPOP_SBC_1	0.0556
p.G12815V	TCGA-BR-6452	STAD	TCGA	PNTST	DEG_SPOP_SBC_1	0.1111
p.G12815V	DO38404	STAD	ICGC	PNTST	DEG_SPOP_SBC_1	0.1111
p.T12820P	TCGA-BR-8680	STAD	TCGA	PNTST	DEG_SPOP_SBC_1	0.25
p.T12820P	DO47769	STAD	ICGC	PNTST	DEG_SPOP_SBC_1	0.25
p.S12821C	TCGA-DG-A2KK	CESC	TCGA	PNTST	DEG_SPOP_SBC_1	0.2778
p.S12821C	DO51595	CESC	ICGC	PNTST	DEG_SPOP_SBC_1	0.2778
p.Q12819E	TCGA-DR-A0ZM	CESC	TCGA	PNTST	DEG_SPOP_SBC_1	0.2222
p.Q12819E	DO6254	CESC	ICGC	PNTST	DEG_SPOP_SBC_1	0.2222
p.G12836W	TCGA-EE-A20C	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	0.0833
p.G12836W	DO47665	SKCM	ICGC	PNTST	DEG_SPOP_SBC_1	0.0833
p.L12835R	TCGA-F5-6814	READ	TCGA	PNTST	DEG_SPOP_SBC_1	0.1111
p.L12835R	DO36556	READ	ICGC	PNTST	DEG_SPOP_SBC_1	0.1111
p.T12817I	TCGA-GF-A6C9	SKCM	TCGA	PNTST	DEG_SPOP_SBC_1	0.1667
p.T12817I	DO51254	SKCM	ICGC	PNTST	DEG_SPOP_SBC_1	0.1667
p.T12825N	DO228971	LICA	ICGC	PNTST	DEG_SPOP_SBC_1	0.7055
p.T12825N	DO229036	LICA	ICGC	PNTST	DEG_SPOP_SBC_1	0.7055
p.L12835F	DO45131	LIRI	ICGC	PNTST	DEG_SPOP_SBC_1	0.1111
p.D12834G	DO228371	MALY	ICGC	PNTST	DEG_SPOP_SBC_1	0.1389
p.D12834G	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	PNTST	DEG_SPOP_SBC_1	0.1389
p.D12834G	ACH-000315	Lymphoma	CCLE	PNTST	DEG_SPOP_SBC_1	0.1389
p.D12834G	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	PNTST	DEG_SPOP_SBC_1	0.1389
p.T12827I	DO220884	MELA	ICGC	PNTST	DEG_SPOP_SBC_1	0.7078
p.A12822V	SIDM00993	Plasma Cell Myeloma	GDSC	PNTST	DEG_SPOP_SBC_1	0.3056
p.A12822V	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	PNTST	DEG_SPOP_SBC_1	0.3056
p.V12813A	SIDM00215	Colorectal Carcinoma	GDSC	PNTST	DEG_SPOP_SBC_1	0.0556
p.V12813A	ACH-000708	Colon/Colorectal Cancer	CCLE	PNTST	DEG_SPOP_SBC_1	0.0556
p.V12813A	SNU-283	large_intestine	COSMIC	PNTST	DEG_SPOP_SBC_1	0.0556
p.N12824Y	SIDM00680	Colorectal Carcinoma	GDSC	PNTST	DEG_SPOP_SBC_1	0.5948
p.N12824Y	ACH-000957	Colon/Colorectal Cancer	CCLE	PNTST	DEG_SPOP_SBC_1	0.5948
p.N12824Y	LS-180	large_intestine	COSMIC	PNTST	DEG_SPOP_SBC_1	0.5948
p.P12823S	SIDM01196	Hepatocellular Carcinoma	GDSC	PNTST	DEG_SPOP_SBC_1	0.6752
p.P12823S	ACH-000422	Liver Cancer	CCLE	PNTST	DEG_SPOP_SBC_1	0.6752
p.P12823S	SNU-475	liver	COSMIC	PNTST	DEG_SPOP_SBC_1	0.6752
p.H12818R	SIDM01012	Other Blood Cancers	GDSC	PNTST	DEG_SPOP_SBC_1	0.1944
p.H12818R	ACH-000346	Leukemia	CCLE	PNTST	DEG_SPOP_SBC_1	0.1944
p.H12818R	JVM-3	haematopoietic_and_lymphoid_tissue	COSMIC	PNTST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q86Z02	Homeodomain-interacting protein kinase 1	DEG_SPOP_SBC_1	565:569	PNTST	SPOP	0.5677	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12823:12827	PNTST	SPOP	0.6675	More...
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_SPOP_SBC_1	1904:1908	PNTST	SPOP	0.8978	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PNTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PNTST