DegronMD

Uniprot ID: Q9P2D1

Source protein: Chromodomain-helicase-DNA-binding protein 7

Source gene: CHD7

Class: DEG_COP1_1

Location: 293:302

E3 ligase: COP1

DEGRON score: 0.8725

ASA_SCORE: 89.51

COIL: 0.9591

CONS_SCORE: 0.3058

DSS_SCORE: 0.6401

HELIX: 0.0192

FCONS_SCORE: 0.9831

RIG_SCORE: 0.647

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S294Y	TCGA-AP-A1DV	UCEC	TCGA	SSRSQTVPSP	DEG_COP1_1	0.6009
p.S294Y	DO43186	UCEC	ICGC	SSRSQTVPSP	DEG_COP1_1	0.6009
p.A284T	TCGA-D1-A1NZ	UCEC	TCGA	SSRSQTVPSP	DEG_COP1_1	0.0833
p.A284T	DO41536	UCEC	ICGC	SSRSQTVPSP	DEG_COP1_1	0.0833
p.P287L	TCGA-HU-A4GN	STAD	TCGA	SSRSQTVPSP	DEG_COP1_1	0.1667
p.P287L	DO233281	GACA	ICGC	SSRSQTVPSP	DEG_COP1_1	0.1667
p.P287L	DO47833	STAD	ICGC	SSRSQTVPSP	DEG_COP1_1	0.1667
p.L290F	DO222743	MELA	ICGC	SSRSQTVPSP	DEG_COP1_1	0.25
p.T289I	DO222875	MELA	ICGC	SSRSQTVPSP	DEG_COP1_1	0.2222
p.R286G	SIDM01265	Plasma Cell Myeloma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.1389
p.R286G	SIDM00930	Osteosarcoma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.1389
p.R286G	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.1389
p.S296N	SIDM00845	Burkitt's Lymphoma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.818
p.S296N	SIDM01519	Head and Neck Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.818
p.S296N	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SSRSQTVPSP	DEG_COP1_1	0.818
p.I304V	SIDM00845	Burkitt's Lymphoma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.2778
p.I304V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	SSRSQTVPSP	DEG_COP1_1	0.2778
p.I304V	SIDM01519	Head and Neck Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.2778
p.I304V	ACH-000786	Lymphoma	CCLE	SSRSQTVPSP	DEG_COP1_1	0.2778
p.I304V	ACH-000992	Head and Neck Cancer	CCLE	SSRSQTVPSP	DEG_COP1_1	0.2778
p.I304V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	SSRSQTVPSP	DEG_COP1_1	0.2778
p.R295Q	SIDM00839	Colorectal Carcinoma	GDSC	SSRSQTVPSP	DEG_COP1_1	0.6218
p.R295Q	LoVo	large_intestine	COSMIC	SSRSQTVPSP	DEG_COP1_1	0.6218

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2D1	Chromodomain-helicase-DNA-binding protein 7	DEG_COP1_1	293:302	SSRSQTVPSP	COP1	0.8725	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons