DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_APCC_DBOX_1

Location: 1068:1076

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8515

ASA_SCORE: 78.7111

COIL: 0.7873

CONS_SCORE: 0.3803

DSS_SCORE: 0.4555

HELIX: 0.1501

FCONS_SCORE: 0.7815

RIG_SCORE: 0.7555

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1083K	TCGA-39-5021	LUSC	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	0.1389
p.T1083K	DO27397	LUSC	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.1389
p.R1073L	TCGA-55-7574	LUAD	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	0.7316
p.R1073L	DO23986	LUAD	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.7316
p.G1077C	TCGA-55-7576	LUAD	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	0.3056
p.G1077C	DO24431	LUAD	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.3056
p.R1078Q	TCGA-A5-A0GW	UCEC	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	0.2778
p.R1078Q	DO41103	UCEC	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.2778
p.R1073W	TCGA-FI-A2D4	UCEC	TCGA	CRVSLRALP	DEG_APCC_DBOX_1	0.7523
p.R1073W	DO43170	UCEC	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.7523
p.A1074T	DO228581	GACA	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.6028
p.A1060V	DO233765	GACA	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.1111
p.I1085M	DO229346	LAML	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00435	Acute Myeloid Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM01034	B-Lymphoblastic Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00608	Plasma Cell Myeloma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00572	Gastric Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00293	Small Cell Lung Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00060	Ovarian Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00252	Biliary Tract Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM01471	Chronic Myelogenous Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM00163	Biliary Tract Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM01451	Pancreatic Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.I1085M	SIDM01618	B-Lymphoblastic Leukemia	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0833
p.A1058G	DO52129	PAEN	ICGC	CRVSLRALP	DEG_APCC_DBOX_1	0.0556
p.M1086I	SIDM00608	Plasma Cell Myeloma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0556
p.M1086I	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.0556
p.M1086I	ACH-000309	Lung Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	0.0556
p.M1086I	ACH-000714	Myeloma	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	0.0556
p.M1086I	SK-LU-1	lung	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	0.0556
p.M1086I	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	0.0556
p.G1067A	SIDM00127	Oral Cavity Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.3056
p.G1067A	JHU-022	upper_aerodigestive_tract	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	0.3056
p.R1078W	SIDM00157	Neuroblastoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.2778
p.R1078W	KP-N-YS	autonomic_ganglia	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	0.2778
p.A1081T	SIDM00487	Colorectal Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.1944
p.A1081T	ACH-000963	Colon/Colorectal Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	0.1944
p.A1081T	CCK-81	large_intestine	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	0.1944
p.V1079A	SIDM00537	Colorectal Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.25
p.V1079A	ACH-001345	Colon/Colorectal Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	0.25
p.V1079A	GP5d	large_intestine	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	0.25
p.R1069S	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	CRVSLRALP	DEG_APCC_DBOX_1	0.7427
p.R1069S	ACH-000596	Lung Cancer	CCLE	CRVSLRALP	DEG_APCC_DBOX_1	0.7427
p.R1069S	LCLC-97TM1	lung	COSMIC	CRVSLRALP	DEG_APCC_DBOX_1	0.7427

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: CRVSLRALP

Degron related mutations and impact score

Drug responses associated with RP1L1 mutations

All proteins holding degron of CRVSLRALP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_APCC_DBOX_1	1068:1076	CRVSLRALP	APC,CDC20,FZR1	0.8515	More...