DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SCF_FBW7_1

Location: 21:28

E3 ligase: FBXW7

DEGRON score: 0.9971

ASA_SCORE: 79.2875

COIL: 0.8023

CONS_SCORE: 0.2354

DSS_SCORE: 0.4255

HELIX: 0.0165

FCONS_SCORE: 1.004

RIG_SCORE: 0.7161

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T24N	TCGA-13-0885	OV	TCGA	VARTPSVT	DEG_SCF_FBW7_1	0.8166
p.T24N	DO30490	OV	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.8166
p.A33D	TCGA-17-Z042	LUAD	TCGA	VARTPSVT	DEG_SCF_FBW7_1	0.1944
p.A33D	TCGA-AA-3977	COAD	TCGA	VARTPSVT	DEG_SCF_FBW7_1	0.1944
p.A33D	DO8730	COAD	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.1944
p.E15D	TCGA-78-7542	LUAD	TCGA	VARTPSVT	DEG_SCF_FBW7_1	0.1667
p.E15D	DO24760	LUAD	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.1667
p.T31M	TCGA-AJ-A3OK	UCEC	TCGA	VARTPSVT	DEG_SCF_FBW7_1	0.25
p.T31M	DO43602	UCEC	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.25
p.P11L	TCGA-EE-A29D	SKCM	TCGA	VARTPSVT	DEG_SCF_FBW7_1	0.0556
p.P11L	DO38123	SKCM	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.0556
p.P11L	SIDM00600	Thyroid Gland Carcinoma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	0.0556
p.P11L	SIDM00368	Small Cell Lung Carcinoma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	0.0556
p.P11L	SIDM00720	Mesothelioma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	0.0556
p.P11L	SIDM01460	Glioma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	0.0556
p.S26L	TCGA-JW-A5VJ	CESC	TCGA	VARTPSVT	DEG_SCF_FBW7_1	0.6556
p.S26L	DO49974	CESC	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.6556
p.T37A	DO222755	COCA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.0833
p.T28N	DO222778	COCA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.7055
p.R14C	DO233869	GACA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.1389
p.K35M	DO229459	SKCA	ICGC	VARTPSVT	DEG_SCF_FBW7_1	0.25
p.P19H	SIDM02021	Esophageal Carcinoma	GDSC	VARTPSVT	DEG_SCF_FBW7_1	0.2778
p.T24S	ACH-001270	Sarcoma	CCLE	VARTPSVT	DEG_SCF_FBW7_1	0.8227

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_1	21:28	VARTPSVT	FBXW7	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons