DegronMD

Uniprot ID: Q8IWN7

Source protein: Retinitis pigmentosa 1-like 1 protein

Source gene: RP1L1

Class: DEG_SCF_FBW7_2

Location: 2228:2234

E3 ligase: FBXW7

DEGRON score: 0.6359

ASA_SCORE: 101.8143

COIL: 0.869

CONS_SCORE: 0.408

DSS_SCORE: 0.9698

HELIX: 0.0803

FCONS_SCORE: 1.2126

RIG_SCORE: 0.5854

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E2229K	TCGA-55-6712	LUAD	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.591
p.E2229K	DO25310	LUAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.591
p.E2240D	TCGA-64-5779	LUAD	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240D	DO24930	LUAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2236D	TCGA-AP-A059	UCEC	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.2778
p.E2236D	DO41361	UCEC	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.2778
p.A2233T	TCGA-AP-A1DV	UCEC	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.6028
p.A2233T	DO43186	UCEC	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.6028
p.P2231L	TCGA-EJ-5525	PRAD	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.7582
p.P2231L	DO36340	PRAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.7582
p.G2243R	TCGA-FW-A3R5	SKCM	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.0833
p.G2243R	DO37406	SKCM	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.0833
p.V2228I	TCGA-QH-A6CZ	LGG	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.5965
p.V2228I	DO50173	LGG	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.5965
p.V2228I	SIDM00433	T-Lymphoblastic Leukemia	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.5965
p.V2228I	SIDM00790	Non-Cancerous	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.5965
p.V2228I	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.5965
p.V2228I	ACH-000795	Leukemia	CCLE	VETPEAE	DEG_SCF_FBW7_2	0.5965
p.V2228I	ACH-002371	Non-Cancerous	CCLE	VETPEAE	DEG_SCF_FBW7_2	0.5965
p.E2219G	TCGA-Z6-A8JE	ESCA	TCGA	VETPEAE	DEG_SCF_FBW7_2	0.0833
p.E2219G	DO228271	MALY	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.0833
p.S2241L	DO222467	BTCA	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.1389
p.S2241L	DO218693	GACA	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.1389
p.T2230A	DO50323	ESAD	ICGC	VETPEAE	DEG_SCF_FBW7_2	0.7139
p.E2240Q	SIDM00672	Hepatocellular Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240Q	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240Q	SIDM01147	Gastric Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240Q	SIDM00863	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240Q	SIDM00808	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240Q	SIDM00628	Breast Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240Q	SIDM01409	Bladder Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2240Q	SIDM01254	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.P2225L	SIDM00672	Hepatocellular Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.P2225L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.P2225L	SIDM01147	Gastric Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.P2225L	SIDM00863	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.P2225L	SIDM00808	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.P2225L	SIDM00628	Breast Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.P2225L	SIDM01409	Bladder Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.P2225L	SIDM01254	Burkitt's Lymphoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.25
p.Q2222L	SIDM01608	Endometrial Carcinoma	GDSC	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.Q2222L	ACH-000990	Endometrial/Uterine Cancer	CCLE	VETPEAE	DEG_SCF_FBW7_2	0.1667
p.E2226Q	ACH-002039	Pancreatic Cancer	CCLE	VETPEAE	DEG_SCF_FBW7_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VETPEAE

Degron related mutations and impact score

Drug responses associated with RP1L1 mutations

All proteins holding degron of VETPEAE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWN7	Retinitis pigmentosa 1-like 1 protein	DEG_SCF_FBW7_2	2228:2234	VETPEAE	FBXW7	0.6359	More...