DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_SCF_FBW7_1

Location: 2757:2764

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 108.675

COIL: 0.9444

CONS_SCORE: 0.3927

DSS_SCORE: 0.615

HELIX: 0.026

FCONS_SCORE: 1.0853

RIG_SCORE: 0.6479

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2759H	TCGA-06-5416	GBM	TCGA	VERTPFSS	DEG_SCF_FBW7_1	0.7133
p.R2759H	DO10880	GBM	ICGC	VERTPFSS	DEG_SCF_FBW7_1	0.7133
p.S2755Y	TCGA-A5-A1OF	UCEC	TCGA	VERTPFSS	DEG_SCF_FBW7_1	0.2778
p.S2755Y	TCGA-KQ-A41N	BLCA	TCGA	VERTPFSS	DEG_SCF_FBW7_1	0.2778
p.S2755Y	DO223588	BLCA	ICGC	VERTPFSS	DEG_SCF_FBW7_1	0.2778
p.S2755Y	DO42568	UCEC	ICGC	VERTPFSS	DEG_SCF_FBW7_1	0.2778
p.P2761L	TCGA-AG-A002	READ	TCGA	VERTPFSS	DEG_SCF_FBW7_1	0.7582
p.S2755T	DO23210	LINC	ICGC	VERTPFSS	DEG_SCF_FBW7_1	0.2778
p.I2756V	SIDM00282	Colorectal Carcinoma	GDSC	VERTPFSS	DEG_SCF_FBW7_1	0.3056
p.I2756V	ACH-000868	Lung Cancer	CCLE	VERTPFSS	DEG_SCF_FBW7_1	0.3056
p.I2756V	ACH-000998	Colon/Colorectal Cancer	CCLE	VERTPFSS	DEG_SCF_FBW7_1	0.3056
p.S2768R	SIDM01504	Small Cell Lung Carcinoma	GDSC	VERTPFSS	DEG_SCF_FBW7_1	0.6667
p.S2768R	ACH-000594	Lung Cancer	CCLE	VERTPFSS	DEG_SCF_FBW7_1	0.6667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SCF_FBW7_1	2757:2764	VERTPFSS	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons