DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_APCC_KENBOX_2

Location: 1981:1985

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5172

ASA_SCORE: 126.84

COIL: 0.8796

CONS_SCORE: 0.3597

DSS_SCORE: 0.7988

HELIX: 0.109

FCONS_SCORE: 0.7576

RIG_SCORE: 0.6029

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1971Y	TCGA-AX-A05Z	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.0556
p.S1971Y	TCGA-D1-A103	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.0556
p.S1971Y	DO40884	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0556
p.S1971Y	DO42312	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0556
p.E1985K	TCGA-ZF-AA4W	BLCA	TCGA	NKENE	DEG_APCC_KENBOX_2	0.591
p.E1985K	DO219089	BLCA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.591
p.P1993A	SIDM02048	Colorectal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.S1973C	SIDM01108	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.S1973C	ACH-000309	Lung Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.1111
p.S1973C	SK-LU-1	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.E1991D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1667
p.E1991D	ACH-000888	Lung Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.1667
p.E1991D	NCI-H1793	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons