DegronMD

Uniprot ID: P30304

Source protein: M-phase inducer phosphatase 1

Source gene: CDC25A

Class: DEG_APCC_KENBOX_2

Location: 140:144

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.593

ASA_SCORE: 103.18

COIL: 0.539

CONS_SCORE: 0.2979

DSS_SCORE: 0.4532

HELIX: 0.4426

FCONS_SCORE: 0.9634

RIG_SCORE: 0.7015

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E139D	TCGA-FT-A3EE	BLCA	TCGA	NKENE	DEG_APCC_KENBOX_2	0.3056
p.E139D	DO720	BLCA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.3056
p.A145D	ACH-001422	Prostate Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.3056
p.F148L	TCGA-CK-4951	COAD	TCGA	NKENE	DEG_APCC_KENBOX_2	0.2222
p.F148L	DO10582	COAD	ICGC	NKENE	DEG_APCC_KENBOX_2	0.2222
p.I131V	SIDM00176	Chondrosarcoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.0833
p.P154T	TCGA-AX-A06F	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.0556
p.P154T	DO41752	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0556
p.D130G	SIDM01307	Colorectal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.0556

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

Showing 1 to 9 of 9 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons