DegronMD - Q14207(NPAT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E1158Q	TCGA-91-6848	LUAD	TCGA	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.1111
p.E1158Q	DO23846	LUAD	ICGC	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.1111
p.N1180H	TCGA-AG-A002	READ	TCGA	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.0556
p.S1159Y	TCGA-AP-A0LM	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.1389
p.S1159Y	DO43306	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.1389
p.V1175A	TCGA-B5-A3FA	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.1944
p.V1175A	DO52402	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.1944
p.P896T	TCGA-BR-7958	STAD	TCGA	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.P896T	DO38344	STAD	ICGC	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.K1167E	TCGA-D1-A2G0	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation altering degron motif	0.7022
p.K1167E	DO43049	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation altering degron motif	0.7022
p.P901L	TCGA-EE-A29E	SKCM	TCGA	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.1944
p.P901L	DO37831	SKCM	ICGC	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.1944
p.D846G	TCGA-EO-A3B0	UCEC	TCGA	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation rewiring degron network	0.2778
p.D846G	DO219773	UCEC	ICGC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation rewiring degron network	0.2778
p.C1172R	TCGA-ET-A39L	THCA	TCGA	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.2778
p.C1172R	DO39110	THCA	ICGC	NKENE	DEG_APCC_KENBOX_2	1166:1170	Mutation rewiring degron network	0.2778
p.N913S	TCGA-IB-7651	PAAD	TCGA	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.3056
p.N913S	DO46657	PAAD	ICGC	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.3056
p.M853L	DO23290	LINC	ICGC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation rewiring degron network	0.0833
p.R911K	DO228368	MALY	ICGC	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation altering degron motif	0.6126
p.P896F	DO222554	MELA	ICGC	LQTPPRS	DEG_SCF_FBW7_1	906:912	Mutation rewiring degron network	0.0556
p.N838D	SIDM00683	Prostate Carcinoma	GDSC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation rewiring degron network	0.3056
p.N838D	LNCaP-Clone-FGC	prostate	COSMIC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation rewiring degron network	0.3056
p.V839I	SIDM00789	Colorectal Carcinoma	GDSC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation altering degron motif	0.5965
p.V839I	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation altering degron motif	0.5965
p.V839I	HCT-15	large intestine	COSMIC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation altering degron motif	0.5965
p.T840I	SIDM00327	Hodgkin's Lymphoma	GDSC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation altering degron motif	0.7078
p.T840I	ACH-000754	Lymphoma	CCLE	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation altering degron motif	0.7078
p.T840I	L-428	haematopoietic and lymphoid tissue	COSMIC	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation altering degron motif	0.7078
p.P841A	ACH-000601	Pancreatic Cancer	CCLE	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation altering degron motif	0.7503
p.G848R	ACH-001234	Lung Cancer	CCLE	VTPCVS	DEG_SCF_FBW7_1	839:844	Mutation rewiring degron network	0.2222

Kaplan plot for NPAT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPAT

UniProt ID: Q14207

Entrez ID: 4863

Protein name: Protein NPAT (Nuclear protein of the ataxia telangiectasia mutated locus) (Nuclear protein of the ATM locus) (p220)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPAT in