DegronMD

Uniprot ID: Q14207

Source protein: Protein NPAT

Source gene: NPAT

Class: DEG_SCF_FBW7_1

Location: 906:912

E3 ligase: FBXW7

DEGRON score: 0.9913

ASA_SCORE: 100.0429

COIL: 0.9531

CONS_SCORE: 0.5372

DSS_SCORE: 0.5442

HELIX: 0.0216

FCONS_SCORE: 1.2965

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P896T	TCGA-BR-7958	STAD	TCGA	LQTPPRS	DEG_SCF_FBW7_1	0.0556
p.P896T	DO38344	STAD	ICGC	LQTPPRS	DEG_SCF_FBW7_1	0.0556
p.P901L	TCGA-EE-A29E	SKCM	TCGA	LQTPPRS	DEG_SCF_FBW7_1	0.1944
p.P901L	DO37831	SKCM	ICGC	LQTPPRS	DEG_SCF_FBW7_1	0.1944
p.N913S	TCGA-IB-7651	PAAD	TCGA	LQTPPRS	DEG_SCF_FBW7_1	0.3056
p.N913S	DO46657	PAAD	ICGC	LQTPPRS	DEG_SCF_FBW7_1	0.3056
p.R911K	DO228368	MALY	ICGC	LQTPPRS	DEG_SCF_FBW7_1	0.6126
p.P896F	DO222554	MELA	ICGC	LQTPPRS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14207	Protein NPAT	DEG_SCF_FBW7_1	906:912	LQTPPRS	FBXW7	0.9913	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons