DegronMD

Uniprot ID: Q14207

Source protein: Protein NPAT

Source gene: NPAT

Class: DEG_SCF_FBW7_1

Location: 839:844

E3 ligase: FBXW7

DEGRON score: 0.8557

ASA_SCORE: 82.4

COIL: 0.855

CONS_SCORE: 0.3595

DSS_SCORE: 0.2113

HELIX: 0.0223

FCONS_SCORE: 0.866

RIG_SCORE: 0.8063

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D846G	TCGA-EO-A3B0	UCEC	TCGA	VTPCVS	DEG_SCF_FBW7_1	0.2778
p.D846G	DO219773	UCEC	ICGC	VTPCVS	DEG_SCF_FBW7_1	0.2778
p.M853L	DO23290	LINC	ICGC	VTPCVS	DEG_SCF_FBW7_1	0.0833
p.N838D	SIDM00683	Prostate Carcinoma	GDSC	VTPCVS	DEG_SCF_FBW7_1	0.3056
p.N838D	LNCaP-Clone-FGC	prostate	COSMIC	VTPCVS	DEG_SCF_FBW7_1	0.3056
p.V839I	SIDM00789	Colorectal Carcinoma	GDSC	VTPCVS	DEG_SCF_FBW7_1	0.5965
p.V839I	ACH-000997	Colon/Colorectal Cancer	CCLE	VTPCVS	DEG_SCF_FBW7_1	0.5965
p.V839I	HCT-15	large_intestine	COSMIC	VTPCVS	DEG_SCF_FBW7_1	0.5965
p.T840I	SIDM00327	Hodgkin's Lymphoma	GDSC	VTPCVS	DEG_SCF_FBW7_1	0.7078
p.T840I	ACH-000754	Lymphoma	CCLE	VTPCVS	DEG_SCF_FBW7_1	0.7078
p.T840I	L-428	haematopoietic_and_lymphoid_tissue	COSMIC	VTPCVS	DEG_SCF_FBW7_1	0.7078
p.P841A	ACH-000601	Pancreatic Cancer	CCLE	VTPCVS	DEG_SCF_FBW7_1	0.7503
p.G848R	ACH-001234	Lung Cancer	CCLE	VTPCVS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14207	Protein NPAT	DEG_SCF_FBW7_1	839:844	VTPCVS	FBXW7	0.8557	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons