DegronMD

Uniprot ID: Q14207

Source protein: Protein NPAT

Source gene: NPAT

Class: DEG_APCC_KENBOX_2

Location: 1166:1170

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9827

ASA_SCORE: 123.78

COIL: 0.7968

CONS_SCORE: 0.4569

DSS_SCORE: 0.5007

HELIX: 0.1688

FCONS_SCORE: 1.244

RIG_SCORE: 0.7143

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1158Q	TCGA-91-6848	LUAD	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1111
p.E1158Q	DO23846	LUAD	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.N1180H	TCGA-AG-A002	READ	TCGA	NKENE	DEG_APCC_KENBOX_2	0.0556
p.S1159Y	TCGA-AP-A0LM	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1389
p.S1159Y	DO43306	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1389
p.V1175A	TCGA-B5-A3FA	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1944
p.V1175A	DO52402	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1944
p.K1167E	TCGA-D1-A2G0	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.7022
p.K1167E	DO43049	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.7022
p.C1172R	TCGA-ET-A39L	THCA	TCGA	NKENE	DEG_APCC_KENBOX_2	0.2778
p.C1172R	DO39110	THCA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons