DegronMD

Uniprot ID: Q96MH7

Source protein: Uncharacterized protein C5orf34

Source gene: C5orf34

Class: DEG_APCC_KENBOX_2

Location: 193:197

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.702

ASA_SCORE: 97.88

COIL: 0.5684

CONS_SCORE: 0.4581

DSS_SCORE: 0.452

HELIX: 0.3896

FCONS_SCORE: 1.213

RIG_SCORE: 0.7592

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E197K	TCGA-37-3789	LUSC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.591
p.E197K	DO26743	LUSC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.591
p.E197V	TCGA-49-AARE	LUAD	TCGA	NKENE	DEG_APCC_KENBOX_2	0.6582
p.E197V	DO218922	LUAD	ICGC	NKENE	DEG_APCC_KENBOX_2	0.6582
p.K204R	TCGA-B5-A3FA	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.25
p.K204R	DO52402	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.25
p.L186V	DO222884	COCA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1389
p.K206E	SIDM00882	Breast Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons