DegronMD

Uniprot ID: Q9HAU5

Source protein: Regulator of nonsense transcripts 2

Source gene: UPF2

Class: DEG_APCC_KENBOX_2

Location: 1083:1087

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9955

ASA_SCORE: 126.32

COIL: 0.8404

CONS_SCORE: 0.2901

DSS_SCORE: 0.7891

HELIX: 0.1442

FCONS_SCORE: 1.041

RIG_SCORE: 0.6443

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1097V	TCGA-DX-AB2V	SARC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.0556
p.I1097V	DO220093	SARC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0556
p.E1087D	TCGA-EE-A2M5	SKCM	TCGA	NKENE	DEG_APCC_KENBOX_2	0.5647
p.E1087D	DO222423	MELA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.5647
p.E1087D	DO37425	SKCM	ICGC	NKENE	DEG_APCC_KENBOX_2	0.5647
p.T1080K	DO229037	LICA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.25
p.V1095A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.V1095A	ACH-000914	Lymphoma	CCLE	NKENE	DEG_APCC_KENBOX_2	0.1111
p.V1095A	HT	haematopoietic_and_lymphoid_tissue	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.E1085D	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.6758
p.E1085D	ACH-000664	Lymphoma	CCLE	NKENE	DEG_APCC_KENBOX_2	0.6758
p.E1085D	SU-DHL-1	haematopoietic_and_lymphoid_tissue	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.6758
p.E1094K	SIDM00140	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1389
p.E1094K	COLO-792	skin	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons