DegronMD - Q9HAU5(UPF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R768H	TCGA-13-0899	OV	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation rewiring degron network	0.1111
p.R768H	DO31120	OV	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation rewiring degron network	0.1111
p.R776W	TCGA-AN-A0AK	BRCA	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation altering degron motif	0.8634
p.R776W	DO1608	BRCA	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation altering degron motif	0.8634
p.K777R	TCGA-B5-A3FA	UCEC	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation altering degron motif	0.6126
p.K777R	DO52402	UCEC	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation altering degron motif	0.6126
p.L783P	TCGA-CJ-4643	KIRC	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation rewiring degron network	0.3056
p.L783P	DO18124	KIRC	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation rewiring degron network	0.3056
p.I1097V	TCGA-DX-AB2V	SARC	TCGA	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.0556
p.I1097V	DO220093	SARC	ICGC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.0556
p.E1087D	TCGA-EE-A2M5	SKCM	TCGA	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation altering degron motif	0.5647
p.E1087D	DO222423	MELA	ICGC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation altering degron motif	0.5647
p.E1087D	DO37425	SKCM	ICGC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation altering degron motif	0.5647
p.R776Q	TCGA-QS-A5YR	UCEC	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation altering degron motif	0.7329
p.R776Q	DO50081	UCEC	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation altering degron motif	0.7329
p.T1080K	DO229037	LICA	ICGC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.25
p.P770C	DO222595	MELA	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation rewiring degron network	0.1667
p.L792F	DO229253	THCA	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	776:782	Mutation rewiring degron network	0.0556
p.V1095A	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.1111
p.V1095A	ACH-000914	Lymphoma	CCLE	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.1111
p.V1095A	HT	haematopoietic and lymphoid tissue	COSMIC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.1111
p.E1085D	SIDM00390	T-Cell Non-Hodgkin's Lymphoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation altering degron motif	0.6758
p.E1085D	ACH-000664	Lymphoma	CCLE	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation altering degron motif	0.6758
p.E1085D	SU-DHL-1	haematopoietic and lymphoid tissue	COSMIC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation altering degron motif	0.6758
p.E1094K	SIDM00140	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.1389
p.E1094K	COLO-792	skin	COSMIC	NKENE	DEG_APCC_KENBOX_2	1083:1087	Mutation rewiring degron network	0.1389

Kaplan plot for UPF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

UPF2

UniProt ID: Q9HAU5

Entrez ID: 26019

Protein name: Regulator of nonsense transcripts 2 (Up-frameshift suppressor 2 homolog) (hUpf2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for UPF2 in