DegronMD

Uniprot ID: Q9HAU5

Source protein: Regulator of nonsense transcripts 2

Source gene: UPF2

Class: LIG_APCC_ABBAyCdc20_2

Location: 776:782

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5658

ASA_SCORE: 47.2

COIL: 0.0624

CONS_SCORE: 0.5485

DSS_SCORE: 0.2607

HELIX: 0.9291

FCONS_SCORE: 1.2031

RIG_SCORE: 0.8704

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R768H	TCGA-13-0899	OV	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R768H	DO31120	OV	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R776W	TCGA-AN-A0AK	BRCA	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.8634
p.R776W	DO1608	BRCA	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.8634
p.K777R	TCGA-B5-A3FA	UCEC	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.6126
p.K777R	DO52402	UCEC	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.6126
p.L783P	TCGA-CJ-4643	KIRC	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.L783P	DO18124	KIRC	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R776Q	TCGA-QS-A5YR	UCEC	TCGA	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.7329
p.R776Q	DO50081	UCEC	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.7329
p.P770C	DO222595	MELA	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.L792F	DO229253	THCA	ICGC	RKLLYKD	LIG_APCC_ABBAyCdc20_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9HAU5	Regulator of nonsense transcripts 2	LIG_APCC_ABBAyCdc20_2	776:782	RKLLYKD	APC,CDC20,FZR1	0.5658	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons