DegronMD

Uniprot ID: Q9H079

Source protein: KATNB1-like protein 1

Source gene: KATNBL1

Class: DEG_APCC_KENBOX_2

Location: 99:103

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7472

ASA_SCORE: 105.14

COIL: 0.6092

CONS_SCORE: 0.4517

DSS_SCORE: 0.3778

HELIX: 0.2856

FCONS_SCORE: 1.1718

RIG_SCORE: 0.7282

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S92N	TCGA-90-7767	LUSC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1389
p.S92N	DO26692	LUSC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1389
p.A105D	TCGA-AP-A059	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.2778
p.A105D	DO41361	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.2778
p.A107T	TCGA-AP-A1DM	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.2222
p.A107T	DO43106	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.2222
p.A98E	DO228952	LICA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.3056
p.H109N	DO229019	LICA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1667
p.P111T	DO229024	LICA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.H109R	SIDM00683	Prostate Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1667
p.H109R	ACH-000977	lymph_node	CCLE	NKENE	DEG_APCC_KENBOX_2	0.1667
p.H109R	LNCaP-Clone-FGC	prostate	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1667
p.D96Y	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.D96Y	ACH-000900	Lung Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.25
p.D96Y	NCI-H23	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons