DegronMD

Uniprot ID: Q9HCK1

Source protein: DBF4-type zinc finger-containing protein 2

Source gene: ZDBF2

Class: DEG_APCC_KENBOX_2

Location: 906:910

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9736

ASA_SCORE: 115.16

COIL: 0.871

CONS_SCORE: 0.7925

DSS_SCORE: 0.5864

HELIX: 0.1026

FCONS_SCORE: 1.1089

RIG_SCORE: 0.6971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q901P	TCGA-55-7576	LUAD	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1944
p.Q901P	DO24431	LUAD	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1944
p.N909I	TCGA-DM-A1D8	COAD	TCGA	NKENE	DEG_APCC_KENBOX_2	0.728
p.N909I	DO8914	COAD	ICGC	NKENE	DEG_APCC_KENBOX_2	0.728
p.E910K	TCGA-EE-A3AE	SKCM	TCGA	NKENE	DEG_APCC_KENBOX_2	0.591
p.E910K	DO37802	SKCM	ICGC	NKENE	DEG_APCC_KENBOX_2	0.591
p.E910K	SIDM00063	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.591
p.V902A	DO233748	GACA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.2222
p.D919A	DO220909	MELA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0833
p.D919E	DO220909	MELA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0833
p.D913Y	SIDM00942	Oral Cavity Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.D913Y	ACH-000518	Head and Neck Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.25
p.D913Y	CAL-33	upper_aerodigestive_tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.25
p.E908K	SIDM00140	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.7022
p.E908K	ACH-000968	Skin Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.7022
p.E908K	COLO-792	skin	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.7022
p.D911Y	CAL-33	upper_aerodigestive_tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.3056
p.E906K	COLO-792	skin	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons