DegronMD

Uniprot ID: Q7Z443

Source protein: Polycystic kidney disease protein 1-like 3

Source gene: PKD1L3

Class: DEG_APCC_KENBOX_2

Location: 1225:1229

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7074

ASA_SCORE: 108.6

COIL: 0.6612

CONS_SCORE: 0.5386

DSS_SCORE: 0.3887

HELIX: 0.3274

FCONS_SCORE: 1.2323

RIG_SCORE: 0.7719

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1232R	SIDM00441	Acute Myeloid Leukemia	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00057	Neuroblastoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM01099	Neuroblastoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00538	Esophageal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM01044	Other Solid Cancers	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00418	Thyroid Gland Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM01079	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00510	Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00983	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00181	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00006	Other Solid Cancers	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00534	Colorectal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.T1232R	SIDM00519	Mesothelioma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25
p.L1236S	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1389
p.L1236S	SIDM00156	Neuroblastoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1389
p.L1236S	SIDM00833	Colorectal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1389
p.P1222S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	NKENE	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENE

Degron related mutations and impact score

Drug responses associated with PKD1L3 mutations

All proteins holding degron of NKENE