DegronMD - Q96MH7(C5orf34)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E197K	TCGA-37-3789	LUSC	TCGA	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation altering degron motif	0.591
p.E197K	DO26743	LUSC	ICGC	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation altering degron motif	0.591
p.E197V	TCGA-49-AARE	LUAD	TCGA	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation altering degron motif	0.6582
p.E197V	DO218922	LUAD	ICGC	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation altering degron motif	0.6582
p.K204R	TCGA-B5-A3FA	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation substituting flanking lysine	0.25
p.K204R	DO52402	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation substituting flanking lysine	0.25
p.L186V	DO222884	COCA	ICGC	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation rewiring degron network	0.1389
p.K206E	SIDM00882	Breast Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	193:197	Mutation substituting flanking lysine	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons