DegronMD

Uniprot ID: Q9UHB9

Source protein: Signal recognition particle subunit SRP68

Source gene: SRP68

Class: DEG_APCC_KENBOX_2

Location: 38:42

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7271

ASA_SCORE: 106.16

COIL: 0.7562

CONS_SCORE: 0.2258

DSS_SCORE: 0.734

HELIX: 0.2036

FCONS_SCORE: 1.0806

RIG_SCORE: 0.6363

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G47R	TCGA-A5-A0G2	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1944
p.G47R	TCGA-AD-6964	COAD	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1944
p.G47R	TCGA-QK-A8Z7	HNSC	TCGA	NKENE	DEG_APCC_KENBOX_2	0.1944
p.G47R	DO8360	COAD	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1944
p.G47R	DO52096	HNSC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1944
p.G47R	DO41235	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1944
p.S45L	TCGA-A8-A08H	BRCA	TCGA	NKENE	DEG_APCC_KENBOX_2	0.25
p.S45L	DO5563	BRCA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.25
p.E40G	TCGA-D8-A147	BRCA	TCGA	NKENE	DEG_APCC_KENBOX_2	0.7199
p.E40G	DO4347	BRCA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.7199
p.R49Q	DO48566	BLCA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.5833
p.R49Q	DO37146	READ	ICGC	NKENE	DEG_APCC_KENBOX_2	0.5833
p.T51A	DO223732	CESC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0833
p.S50P	DO7780	COAD	ICGC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.E36G	DO233266	GACA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.2778
p.E36G	DO233192	GACA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.2778
p.M28R	DO22237	LGG	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0556
p.Q38K	DO229032	LICA	ICGC	NKENE	DEG_APCC_KENBOX_2	0.6944
p.R51Q	DO43306	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0833
p.R51Q	DO41572	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	0.0833
p.E36V	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.2778
p.E36V	NCI-H1838	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.2778
p.G47A	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.1944
p.G47A	ACH-000893	Lung Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.1944
p.G47A	NCI-H1651	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1944
p.E37V	SIDM01190	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.3056
p.E37V	ACH-000720	Bladder Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.3056
p.E37V	TCCSUP	urinary_tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.3056
p.E37K	SIDM01190	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	0.3056
p.E37K	ACH-000720	Bladder Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	0.3056
p.E37K	TCCSUP	urinary_tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.3056
p.S50L	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1111
p.G50W	NCI-H250	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1981:1985	NKENE	APC,CDC20,FZR1	0.5172	More...
P30304	M-phase inducer phosphatase 1	DEG_APCC_KENBOX_2	140:144	NKENE	APC,CDC20,FZR1	0.593	More...
Q14207	Protein NPAT	DEG_APCC_KENBOX_2	1166:1170	NKENE	APC,CDC20,FZR1	0.9827	More...
Q7Z443	Polycystic kidney disease protein 1-like 3	DEG_APCC_KENBOX_2	1225:1229	NKENE	APC,CDC20,FZR1	0.7074	More...
Q9H079	KATNB1-like protein 1	DEG_APCC_KENBOX_2	99:103	NKENE	APC,CDC20,FZR1	0.7472	More...
Q9HAU5	Regulator of nonsense transcripts 2	DEG_APCC_KENBOX_2	1083:1087	NKENE	APC,CDC20,FZR1	0.9955	More...
Q9UHB9	Signal recognition particle subunit SRP68	DEG_APCC_KENBOX_2	38:42	NKENE	APC,CDC20,FZR1	0.7271	More...
Q9HCK1	DBF4-type zinc finger-containing protein 2	DEG_APCC_KENBOX_2	906:910	NKENE	APC,CDC20,FZR1	0.9736	More...
Q96MH7	Uncharacterized protein C5orf34	DEG_APCC_KENBOX_2	193:197	NKENE	APC,CDC20,FZR1	0.702	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKENE

Degron related mutations and impact score

Drug responses associated with SRP68 mutations

All proteins holding degron of NKENE