DegronMD - Q9UHB9(SRP68)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G47R	TCGA-A5-A0G2	UCEC	TCGA	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.G47R	TCGA-AD-6964	COAD	TCGA	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.G47R	TCGA-QK-A8Z7	HNSC	TCGA	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.G47R	DO8360	COAD	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.G47R	DO52096	HNSC	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.G47R	DO41235	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.S45L	TCGA-A8-A08H	BRCA	TCGA	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.25
p.S45L	DO5563	BRCA	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.25
p.E40G	TCGA-D8-A147	BRCA	TCGA	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation altering degron motif	0.7199
p.E40G	DO4347	BRCA	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation altering degron motif	0.7199
p.R49Q	DO48566	BLCA	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation blocking ubiquitination signal	0.5833
p.R49Q	DO37146	READ	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation blocking ubiquitination signal	0.5833
p.T51A	DO223732	CESC	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.0833
p.S50P	DO7780	COAD	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1111
p.E36G	DO233266	GACA	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.2778
p.E36G	DO233192	GACA	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.2778
p.M28R	DO22237	LGG	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.0556
p.Q38K	DO229032	LICA	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation altering degron motif	0.6944
p.R51Q	DO43306	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.0833
p.R51Q	DO41572	UCEC	ICGC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.0833
p.E36V	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.2778
p.E36V	NCI-H1838	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.2778
p.G47A	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.G47A	ACH-000893	Lung Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.G47A	NCI-H1651	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1944
p.E37V	SIDM01190	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.3056
p.E37V	ACH-000720	Bladder Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.3056
p.E37V	TCCSUP	urinary tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.3056
p.E37K	SIDM01190	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.3056
p.E37K	ACH-000720	Bladder Cancer	CCLE	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.3056
p.E37K	TCCSUP	urinary tract	COSMIC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.3056
p.S50L	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1111
p.G50W	NCI-H250	lung	COSMIC	NKENE	DEG_APCC_KENBOX_2	38:42	Mutation rewiring degron network	0.1111

Kaplan plot for SRP68 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SRP68

UniProt ID: Q9UHB9

Entrez ID: 6730

Protein name: Signal recognition particle subunit SRP68 (SRP68) (Signal recognition particle 68 kDa protein)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SRP68 in