DegronMD - Q7Z443(PKD1L3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1232R	SIDM00441	Acute Myeloid Leukemia	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00447	B-Lymphoblastic Leukemia	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00057	Neuroblastoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM01099	Neuroblastoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00538	Esophageal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM01044	Other Solid Cancers	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00418	Thyroid Gland Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM01079	Melanoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00510	Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00983	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00181	Bladder Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00006	Other Solid Cancers	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00534	Colorectal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00738	Non-Small Cell Lung Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.T1232R	SIDM00519	Mesothelioma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25
p.L1236S	SIDM01058	B-Cell Non-Hodgkin's Lymphoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.1389
p.L1236S	SIDM00156	Neuroblastoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.1389
p.L1236S	SIDM00833	Colorectal Carcinoma	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.1389
p.P1222S	SIDM00121	T-Lymphoblastic Leukemia	GDSC	NKENE	DEG_APCC_KENBOX_2	1225:1229	Mutation rewiring degron network	0.25

Kaplan plot for PKD1L3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PKD1L3

UniProt ID: Q7Z443

Entrez ID: 342372

Protein name: Polycystic kidney disease protein 1-like 3 (PC1-like 3 protein) (Polycystin-1L3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PKD1L3 in