DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_SPOP_SBC_1

Location: 336:340

E3 ligase: SPOP

DEGRON score: 0.9067

ASA_SCORE: 46.98

COIL: 0.5024

CONS_SCORE: 0.5195

DSS_SCORE: 0.3289

HELIX: 0.498

FCONS_SCORE: 0.9853

RIG_SCORE: 0.7287

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D328Y	TCGA-2Z-A9JR	KIRP	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1111
p.D328Y	DO219685	KIRP	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1111
p.S331P	TCGA-A5-A1OF	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.6389
p.S331P	DO42568	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.6389
p.R332Q	TCGA-EI-6917	READ	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2222
p.R332Q	DO36881	READ	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2222
p.Q341L	DO225037	BRCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.3056
p.Q341L	DO227629	BRCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.3056
p.D326Y	DO233904	GACA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.D329Y	DO228985	LICA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1389
p.M347V	DO35242	PACA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1389
p.D328V	DO51495	PACA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1111
p.S331L	SIDM00534	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6389
p.S331L	ACH-000986	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.6389
p.S331L	HT-115	large_intestine	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.6389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons