DegronMD

Uniprot ID: Q5T6F2

Source protein: Ubiquitin-associated protein 2

Source gene: UBAP2

Class: DEG_SPOP_SBC_1

Location: 612:616

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 85.66

COIL: 0.9358

CONS_SCORE: 0.4547

DSS_SCORE: 0.4423

HELIX: 0.0416

FCONS_SCORE: 0.9743

RIG_SCORE: 0.655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D618H	TCGA-A7-A13F	BRCA	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2778
p.D618H	DO4098	BRCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2778
p.H623N	TCGA-CZ-5459	KIRC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1389
p.H623N	DO17452	KIRC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1389
p.M613V	TCGA-DK-A3IK	BLCA	TCGA	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M613V	DO454	BLCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.R625G	TCGA-MP-A4T4	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.0833
p.R625G	DO45357	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0833
p.N606S	DO229010	COCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.N606S	DO229005	COCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.N606S	DO229505	LAML	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.N606S	DO230993	LUSC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.N606S	DO231007	LUSC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.P610T	DO229027	LICA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2778
p.N624K	DO229041	LICA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1111
p.S614T	DO50886	LICA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.6005
p.S621T	SIDM00524	Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.1944
p.S621T	ACH-000703	Lung Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.1944
p.S621T	DMS-79	lung	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.1944
p.R625K	SIDM00572	Gastric Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.0833
p.R625K	SIDM01040	Ovarian Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.0833
p.R625K	SIDM00192	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.0833
p.S602R	SIDM01588	Endometrial Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.S602R	ACH-000993	Endometrial/Uterine Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons