DegronMD - Q96MP8(KCTD7)

FUNCTION: May be involved in the control of excitability of cortical neurons. {ECO:0000250}.

GO - Biological processes (BP): cellular potassium ion homeostasis [GO:0030007]; glutamate homeostasis [GO:0090461]; membrane hyperpolarization [GO:0060081]; positive regulation of transporter activity [GO:0032411]; protein homooligomerization [GO:0051260]

GO - Molecular function (MF): identical protein binding [GO:0042802]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A30D	DO234385	ESAD	ICGC	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation altering degron motif	0.7793
p.G33D	DO227752	COCA	ICGC	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation altering degron motif	0.7198
p.P33Q	DO229088	THCA	ICGC	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation altering degron motif	0.7035
p.L17V	DO15334	HNSC	ICGC	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.6765
p.T34M	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation altering degron motif	0.6312
p.M18V	ACH-001518	Endometrial/Uterine Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.6097
p.A17V	DO229103	THCA	ICGC	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation altering degron motif	0.5825
p.E29V	DO229204	THCA	ICGC	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation rewiring degron network	0.3056
p.G16C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.3056
p.G16C	ACH-000912	Lung Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.3056
p.A23S	TCGA-EE-A29X	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A23S	DO37595	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.A38V	ACH-000651	Colon/Colorectal Cancer	CCLE	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation rewiring degron network	0.2778
p.A23T	ACH-000994	Endometrial/Uterine Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2778
p.G27V	DO38404	STAD	ICGC	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation rewiring degron network	0.25
p.D13N	DO50284	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.R13C	SIDM01577	Plasma Cell Myeloma	GDSC	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.R13C	ACH-000889	Myeloma	CCLE	AMSSS	DEG_SPOP_SBC_1	17:21	Mutation rewiring degron network	0.2222
p.A41S	DO228978	LICA	ICGC	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation rewiring degron network	0.1944
p.E41K	DO42033	UCEC	ICGC	PATPTAT	DEG_SCF_FBW7_1	30:36	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 26 entries

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Kaplan plot for KCTD7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCTD7

UniProt ID: Q96MP8

Entrez ID: 154881

Protein name: BTB/POZ domain-containing protein KCTD7

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCTD7 in