DegronMD

Uniprot ID: Q96MP8

Source protein: BTB/POZ domain-containing protein KCTD7

Source gene: KCTD7

Class: DEG_SCF_FBW7_1

Location: 30:36

E3 ligase: FBXW7

DEGRON score: 0.9524

ASA_SCORE: 79.0714

COIL: 0.8311

CONS_SCORE: 0.2885

DSS_SCORE: 0.6345

HELIX: 0.1501

FCONS_SCORE: 0.8683

RIG_SCORE: 0.6644

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A23S	TCGA-EE-A29X	SKCM	TCGA	PATPTAT	DEG_SCF_FBW7_1	0.1389
p.A23S	DO37595	SKCM	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.1389
p.G33D	DO227752	COCA	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.7198
p.A30D	DO234385	ESAD	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.7793
p.A41S	DO228978	LICA	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.1944
p.G27V	DO38404	STAD	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.25
p.E29V	DO229204	THCA	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.3056
p.P33Q	DO229088	THCA	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.7035
p.E41K	DO42033	UCEC	ICGC	PATPTAT	DEG_SCF_FBW7_1	0.1944
p.A38V	ACH-000651	Colon/Colorectal Cancer	CCLE	PATPTAT	DEG_SCF_FBW7_1	0.2778
p.A23T	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATPTAT	DEG_SCF_FBW7_1	0.1389
p.T34M	ACH-000994	Endometrial/Uterine Cancer	CCLE	PATPTAT	DEG_SCF_FBW7_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SCF_FBW7_1	30:36	PATPTAT	FBXW7	0.9524	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons