DegronMD

Uniprot ID: Q96MP8

Source protein: BTB/POZ domain-containing protein KCTD7

Source gene: KCTD7

Class: DEG_SPOP_SBC_1

Location: 17:21

E3 ligase: SPOP

DEGRON score: 0.8897

ASA_SCORE: 79.06

COIL: 0.8836

CONS_SCORE: 0.2798

DSS_SCORE: 0.7345

HELIX: 0.0762

FCONS_SCORE: 0.8633

RIG_SCORE: 0.5903

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A23S	TCGA-EE-A29X	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2778
p.A23S	DO37595	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2778
p.L17V	DO15334	HNSC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.6765
p.H11N	DO229050	LICA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.D13N	DO50284	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2222
p.G27V	DO38404	STAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.A17V	DO229103	THCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.5825
p.E29V	DO229204	THCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1111
p.G16C	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.3056
p.G16C	ACH-000912	Lung Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.3056
p.R13C	SIDM01577	Plasma Cell Myeloma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.2222
p.R13C	ACH-000889	Myeloma	CCLE	AMSSS	DEG_SPOP_SBC_1	0.2222
p.A23T	ACH-000994	Endometrial/Uterine Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.2778
p.M18V	ACH-001518	Endometrial/Uterine Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.6097

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons