DegronMD

Uniprot ID: P19532

Source protein: Transcription factor E3

Source gene: TFE3

Class: DEG_SPOP_SBC_1

Location: 105:109

E3 ligase: SPOP

DEGRON score: 0.8575

ASA_SCORE: 83.7

COIL: 0.8474

CONS_SCORE: 0.6195

DSS_SCORE: 0.6459

HELIX: 0.1278

FCONS_SCORE: 0.9538

RIG_SCORE: 0.5498

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G100C	TCGA-58-8388	LUSC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1944
p.S111L	TCGA-EB-A431	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2778
p.S111L	DO37671	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2778
p.M106R	TCGA-EE-A2MS	SKCM	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7521
p.M106R	DO37567	SKCM	ICGC	AMSSS	DEG_SPOP_SBC_1	0.7521
p.S107L	TCGA-FI-A2D5	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7667
p.S107L	DO41331	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.7667
p.V114D	DO231495	THCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons