DegronMD - Q8TED9(AFAP1L1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S177G	TCGA-A6-3809	COAD	TCGA	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.S177G	DO8722	COAD	ICGC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1389
p.A184T	TCGA-AX-A2HD	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.A184T	DO42608	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation altering degron motif	0.7139
p.S191T	TCGA-BR-6452	STAD	TCGA	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.S191T	DO38404	STAD	ICGC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.25
p.K176N	TCGA-D7-A74A	STAD	TCGA	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation substituting flanking lysine	0.2222
p.K176N	DO50123	STAD	ICGC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation substituting flanking lysine	0.2222
p.E196Q	TCGA-DK-A3X1	BLCA	TCGA	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.E196Q	DO447	BLCA	ICGC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.1111
p.E197D	SIDM00781	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.E197D	SIDM00780	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.E197D	ACH-000967	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.E197D	ACH-001199	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833
p.E197D	SNU-C2B	large intestine	COSMIC	AMSSS	DEG_SPOP_SBC_1	184:188	Mutation rewiring degron network	0.0833

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons