DegronMD

Uniprot ID: P12034

Source protein: Fibroblast growth factor 5

Source gene: FGF5

Class: DEG_SPOP_SBC_1

Location: 53:57

E3 ligase: SPOP

DEGRON score: 0.9021

ASA_SCORE: 79.02

COIL: 0.8266

CONS_SCORE: 0.4812

DSS_SCORE: 0.6664

HELIX: 0.1382

FCONS_SCORE: 0.9765

RIG_SCORE: 0.4756

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q48P	TCGA-22-4613	LUSC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1944
p.Q48P	DO26468	LUSC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1944
p.P63A	TCGA-62-A46O	LUAD	TCGA	AMSSS	DEG_SPOP_SBC_1	0.1667
p.P63A	DO26240	LUAD	ICGC	AMSSS	DEG_SPOP_SBC_1	0.1667
p.S49I	TCGA-A5-A0G2	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.2222
p.S49I	DO41235	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2222
p.S44P	TCGA-A5-A0VP	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.0833
p.S44P	DO42600	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.0833
p.A53T	TCGA-AX-A0J1	UCEC	TCGA	AMSSS	DEG_SPOP_SBC_1	0.7139
p.A53T	DO233823	GACA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.7139
p.A53T	DO41199	UCEC	ICGC	AMSSS	DEG_SPOP_SBC_1	0.7139
p.A59T	DO233737	GACA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.2778
p.S52N	DO232761	PBCA	ICGC	AMSSS	DEG_SPOP_SBC_1	0.3056
p.M54V	SIDM00845	Burkitt's Lymphoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01090	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00967	Ovarian Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01126	Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00633	Breast Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00654	Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00447	B-Lymphoblastic Leukemia	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00529	Breast Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00875	Breast Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00032	Bladder Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01147	Gastric Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00793	Burkitt's Lymphoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01133	Other Solid Cancers	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00068	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00721	Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00720	Mesothelioma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM00808	Burkitt's Lymphoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01387	Small Cell Lung Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01763	Rhabdomyosarcoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01254	Burkitt's Lymphoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.M54V	SIDM01525	Acute Myeloid Leukemia	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6097
p.L67P	SIDM00845	Burkitt's Lymphoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.0556
p.M54I	SIDM00660	Colorectal Carcinoma	GDSC	AMSSS	DEG_SPOP_SBC_1	0.6507
p.M54I	ACH-000985	Colon/Colorectal Cancer	CCLE	AMSSS	DEG_SPOP_SBC_1	0.6507
p.M54I	LS-411N	large_intestine	COSMIC	AMSSS	DEG_SPOP_SBC_1	0.6507

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P12034	Fibroblast growth factor 5	DEG_SPOP_SBC_1	53:57	AMSSS	SPOP	0.9021	More...
P19532	Transcription factor E3	DEG_SPOP_SBC_1	105:109	AMSSS	SPOP	0.8575	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	336:340	AMSSS	SPOP	0.9067	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	612:616	AMSSS	SPOP	0.9968	More...
Q68CP9	AT-rich interactive domain-containing protein 2	DEG_SPOP_SBC_1	987:991	AMSSS	SPOP	0.8843	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1466:1470	AMSSS	SPOP	0.9941	More...
Q8N556	Actin filament-associated protein 1	DEG_SPOP_SBC_1	117:121	AMSSS	SPOP	0.9445	More...
Q8TED9	Actin filament-associated protein 1-like 1	DEG_SPOP_SBC_1	184:188	AMSSS	SPOP	0.9977	More...
Q96MP8	BTB/POZ domain-containing protein KCTD7	DEG_SPOP_SBC_1	17:21	AMSSS	SPOP	0.8897	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AMSSS

Degron related mutations and impact score

Drug responses associated with FGF5 mutations

All proteins holding degron of AMSSS