DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_APCC_KENBOX_2

Location: 1884:1888

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8467

ASA_SCORE: 117.94

COIL: 0.385

CONS_SCORE: 0.3755

DSS_SCORE: 0.568

HELIX: 0.6224

FCONS_SCORE: 1.0634

RIG_SCORE: 0.6561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1882S	TCGA-61-1919	OV	TCGA	AKENK	DEG_APCC_KENBOX_2	0.2778
p.R1882S	DO32410	OV	ICGC	AKENK	DEG_APCC_KENBOX_2	0.2778
p.A1892V	TCGA-B5-A11E	UCEC	TCGA	AKENK	DEG_APCC_KENBOX_2	0.2222
p.A1892V	DO41644	UCEC	ICGC	AKENK	DEG_APCC_KENBOX_2	0.2222
p.E1880K	TCGA-B5-A11R	UCEC	TCGA	AKENK	DEG_APCC_KENBOX_2	0.2222
p.E1880K	DO43787	UCEC	ICGC	AKENK	DEG_APCC_KENBOX_2	0.2222
p.E1886K	TCGA-B5-A3FA	UCEC	TCGA	AKENK	DEG_APCC_KENBOX_2	0.7022
p.E1886K	DO52402	UCEC	ICGC	AKENK	DEG_APCC_KENBOX_2	0.7022
p.A1884S	TCGA-CZ-5468	KIRC	TCGA	AKENK	DEG_APCC_KENBOX_2	0.6477
p.A1884S	DO18332	KIRC	ICGC	AKENK	DEG_APCC_KENBOX_2	0.6477
p.K1888N	TCGA-D3-A3CE	SKCM	TCGA	AKENK	DEG_APCC_KENBOX_2	0.5806
p.K1888N	DO37405	SKCM	ICGC	AKENK	DEG_APCC_KENBOX_2	0.5806
p.A1879S	TCGA-D5-6926	COAD	TCGA	AKENK	DEG_APCC_KENBOX_2	0.1944
p.A1879S	DO8530	COAD	ICGC	AKENK	DEG_APCC_KENBOX_2	0.1944
p.E1891Q	TCGA-XF-A9T8	BLCA	TCGA	AKENK	DEG_APCC_KENBOX_2	0.25
p.E1891Q	DO51927	BLCA	ICGC	AKENK	DEG_APCC_KENBOX_2	0.25
p.S1890L	SIDM00290	Gastric Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.2778
p.S1890L	ACH-000847	Gastric Cancer	CCLE	AKENK	DEG_APCC_KENBOX_2	0.2778
p.S1890L	HGC-27	stomach	COSMIC	AKENK	DEG_APCC_KENBOX_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1884:1888	AKENK	APC,CDC20,FZR1	0.8467	More...
Q6ZSZ6	Teashirt homolog 1	DEG_APCC_KENBOX_2	674:678	AKENK	APC,CDC20,FZR1	0.9929	More...
Q9BRD0	BUD13 homolog	DEG_APCC_KENBOX_2	554:558	AKENK	APC,CDC20,FZR1	0.5673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons