DegronMD

Uniprot ID: Q9BRD0

Source protein: BUD13 homolog

Source gene: BUD13

Class: DEG_APCC_KENBOX_2

Location: 554:558

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5673

ASA_SCORE: 116.5

COIL: 0.5782

CONS_SCORE: 0.4567

DSS_SCORE: 0.6031

HELIX: 0.4212

FCONS_SCORE: 0.7611

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R565C	TCGA-06-5417	GBM	TCGA	AKENK	DEG_APCC_KENBOX_2	0.1389
p.A554D	TCGA-DX-A6YT	SARC	TCGA	AKENK	DEG_APCC_KENBOX_2	0.6682
p.S567G	TCGA-F7-A624	HNSC	TCGA	AKENK	DEG_APCC_KENBOX_2	0.5278
p.S567G	SIDM01608	Endometrial Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.5278
p.A546S	TCGA-GV-A3QF	BLCA	TCGA	AKENK	DEG_APCC_KENBOX_2	0.1111
p.M545I	TCGA-GV-A3QF	BLCA	TCGA	AKENK	DEG_APCC_KENBOX_2	0.0833
p.K551R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.3611
p.K551R	NCI-H1568	lung	COSMIC	AKENK	DEG_APCC_KENBOX_2	0.3611

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1884:1888	AKENK	APC,CDC20,FZR1	0.8467	More...
Q6ZSZ6	Teashirt homolog 1	DEG_APCC_KENBOX_2	674:678	AKENK	APC,CDC20,FZR1	0.9929	More...
Q9BRD0	BUD13 homolog	DEG_APCC_KENBOX_2	554:558	AKENK	APC,CDC20,FZR1	0.5673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons