DegronMD - Q9BRD0(BUD13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R565C	TCGA-06-5417	GBM	TCGA	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.1389
p.A554D	TCGA-DX-A6YT	SARC	TCGA	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation altering degron motif	0.6682
p.S567G	TCGA-F7-A624	HNSC	TCGA	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation blocking phosphorylation signal	0.5278
p.S567G	SIDM01608	Endometrial Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation blocking phosphorylation signal	0.5278
p.A546S	TCGA-GV-A3QF	BLCA	TCGA	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.1111
p.M545I	TCGA-GV-A3QF	BLCA	TCGA	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation rewiring degron network	0.0833
p.K551R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation substituting flanking lysine	0.3611
p.K551R	NCI-H1568	lung	COSMIC	AKENK	DEG_APCC_KENBOX_2	554:558	Mutation substituting flanking lysine	0.3611

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons