DegronMD

Uniprot ID: Q6ZSZ6

Source protein: Teashirt homolog 1

Source gene: TSHZ1

Class: DEG_APCC_KENBOX_2

Location: 674:678

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9929

ASA_SCORE: 113.14

COIL: 0.592

CONS_SCORE: 0.4834

DSS_SCORE: 0.6247

HELIX: 0.4052

FCONS_SCORE: 1.1699

RIG_SCORE: 0.6387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L666P	DO229010	COCA	ICGC	AKENK	DEG_APCC_KENBOX_2	0.1111
p.L666P	DO234285	ESAD	ICGC	AKENK	DEG_APCC_KENBOX_2	0.1111
p.L666P	DO229480	LAML	ICGC	AKENK	DEG_APCC_KENBOX_2	0.1111
p.L666P	DO229505	LAML	ICGC	AKENK	DEG_APCC_KENBOX_2	0.1111
p.A669T	DO16037	HNSC	ICGC	AKENK	DEG_APCC_KENBOX_2	0.1944
p.G688C	DO229037	LICA	ICGC	AKENK	DEG_APCC_KENBOX_2	0.0556
p.P672H	DO26898	LUSC	ICGC	AKENK	DEG_APCC_KENBOX_2	0.2778
p.S687I	DO220011	SARC	ICGC	AKENK	DEG_APCC_KENBOX_2	0.0833
p.T683M	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.1944
p.T683M	SIDM01164	Glioma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.1944
p.T683M	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.1944
p.K678E	SIDM00698	Small Cell Lung Carcinoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.591
p.K678E	ACH-000506	Lung Cancer	CCLE	AKENK	DEG_APCC_KENBOX_2	0.591
p.K678E	NCI-H146	lung	COSMIC	AKENK	DEG_APCC_KENBOX_2	0.591
p.P681L	SIDM01107	Melanoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.25
p.P681L	SIDM00900	Non-Cancerous	GDSC	AKENK	DEG_APCC_KENBOX_2	0.25
p.P681L	SIDM01397	Melanoma	GDSC	AKENK	DEG_APCC_KENBOX_2	0.25
p.A670V	ACH-001610	Brain Cancer	CCLE	AKENK	DEG_APCC_KENBOX_2	0.2222
p.P681S	ACH-001656	Leukemia	CCLE	AKENK	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	1884:1888	AKENK	APC,CDC20,FZR1	0.8467	More...
Q6ZSZ6	Teashirt homolog 1	DEG_APCC_KENBOX_2	674:678	AKENK	APC,CDC20,FZR1	0.9929	More...
Q9BRD0	BUD13 homolog	DEG_APCC_KENBOX_2	554:558	AKENK	APC,CDC20,FZR1	0.5673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons