DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_APCC_KENBOX_2

Location: 2601:2605

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9747

ASA_SCORE: 114.32

COIL: 0.8968

CONS_SCORE: 0.3402

DSS_SCORE: 0.5815

HELIX: 0.0532

FCONS_SCORE: 0.8692

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2601R	TCGA-AB-2827	LAML	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.6316
p.S2601R	DO22032	LAML	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.6316
p.R2613I	TCGA-AJ-A3EL	UCEC	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.1111
p.R2613I	DO41542	UCEC	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.1111
p.S2596A	SIDM00057	Neuroblastoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	0.1944
p.S2596A	ACH-000676	Brain Cancer	CCLE	SKENQ	DEG_APCC_KENBOX_2	0.1944
p.S2596A	ACH-002389	Neuroblastoma	CCLE	SKENQ	DEG_APCC_KENBOX_2	0.1944
p.S2596A	ACN	autonomic_ganglia	COSMIC	SKENQ	DEG_APCC_KENBOX_2	0.1944
p.A2608T	SIDM01588	Endometrial Carcinoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	0.25
p.A2608T	ACH-000993	Endometrial/Uterine Cancer	CCLE	SKENQ	DEG_APCC_KENBOX_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	2601:2605	SKENQ	APC,CDC20,FZR1	0.9747	More...
Q12834	Cell division cycle protein 20 homolog	DEG_APCC_KENBOX_2	96:100	SKENQ	APC,CDC20,FZR1	0.985	More...
Q13683	Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]	DEG_APCC_KENBOX_2	118:122	SKENQ	APC,CDC20,FZR1	0.9673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons