DegronMD

Uniprot ID: Q13683

Source protein: Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

Source gene: ITGA7

Class: DEG_APCC_KENBOX_2

Location: 118:122

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9673

ASA_SCORE: 78.84

COIL: 0.8334

CONS_SCORE: 0.5048

DSS_SCORE: 0.482

HELIX: 0.0348

FCONS_SCORE: 1.2012

RIG_SCORE: 0.7631

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R129W	TCGA-A8-A094	BRCA	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.R129W	TCGA-ER-A193	SKCM	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.R129W	TCGA-FW-A3R5	SKCM	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.R129W	DO2593	BRCA	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.R129W	DO37406	SKCM	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.R129W	DO47368	SKCM	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.E120D	TCGA-CA-6717	COAD	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.6758
p.E120D	DO8264	COAD	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.6758
p.D109N	TCGA-DK-A6AW	BLCA	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.0833
p.D109N	TCGA-EO-A22R	UCEC	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.0833
p.D109N	DO48566	BLCA	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.0833
p.D109N	DO42713	UCEC	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.0833
p.R129L	TCGA-EO-A22X	UCEC	TCGA	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.R129L	DO43907	UCEC	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.1389
p.S118C	DO234276	ESAD	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.643
p.E117G	DO234276	ESAD	ICGC	SKENQ	DEG_APCC_KENBOX_2	0.3056
p.M114V	SIDM01090	Colorectal Carcinoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	0.2222
p.Y114H	SNU-C5	large_intestine	COSMIC	SKENQ	DEG_APCC_KENBOX_2	0.2222
p.E132K	HGC-27	stomach	COSMIC	SKENQ	DEG_APCC_KENBOX_2	0.0556
p.H113N	FADU	upper_aerodigestive_tract	COSMIC	SKENQ	DEG_APCC_KENBOX_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	2601:2605	SKENQ	APC,CDC20,FZR1	0.9747	More...
Q12834	Cell division cycle protein 20 homolog	DEG_APCC_KENBOX_2	96:100	SKENQ	APC,CDC20,FZR1	0.985	More...
Q13683	Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]	DEG_APCC_KENBOX_2	118:122	SKENQ	APC,CDC20,FZR1	0.9673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons