DegronMD - Q12834(CDC20)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P71A	TCGA-69-7978	LUAD	TCGA	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1111
p.P71A	DO24920	LUAD	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1111
p.Q68R	TCGA-75-6214	LUAD	TCGA	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944
p.Q68R	DO24830	LUAD	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.1944
p.A46S	DO229022	LICA	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0556
p.R499C	DO222837	MELA	ICGC	GIR	DEG_APCC_TPR_1	497:499	Mutation altering degron motif	0.8301
p.R499C	SIDM00217	Colorectal Carcinoma	GDSC	GIR	DEG_APCC_TPR_1	497:499	Mutation altering degron motif	0.8301
p.R499C	ACH-000999	Colon/Colorectal Cancer	CCLE	GIR	DEG_APCC_TPR_1	497:499	Mutation altering degron motif	0.8301
p.R499C	SNU-1040	large intestine	COSMIC	GIR	DEG_APCC_TPR_1	497:499	Mutation altering degron motif	0.8301
p.A46T	DO229221	THCA	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation rewiring degron network	0.0556
p.G57R	SIDM01136	Pancreatic Carcinoma	GDSC	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.6457
p.G57R	ACH-000417	Pancreatic Cancer	CCLE	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.6457
p.G57R	PANC-08-13	pancreas	COSMIC	PGRTPGKS	DEG_SCF_FBW7_1	56:63	Mutation altering degron motif	0.6457
p.T106A	SIDM00118	Colorectal Carcinoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	96:100	Mutation blocking phosphorylation signal	0.6111
p.T106A	ACH-001081	Colon/Colorectal Cancer	CCLE	SKENQ	DEG_APCC_KENBOX_2	96:100	Mutation blocking phosphorylation signal	0.6111
p.T106A	HCC2998	large intestine	COSMIC	SKENQ	DEG_APCC_KENBOX_2	96:100	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for CDC20 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDC20

UniProt ID: Q12834

Entrez ID: 991

Protein name: Cell division cycle protein 20 homolog (p55CDC)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDC20 in