DegronMD

Uniprot ID: Q12834

Source protein: Cell division cycle protein 20 homolog

Source gene: CDC20

Class: DEG_APCC_KENBOX_2

Location: 96:100

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.985

ASA_SCORE: 110.46

COIL: 0.86

CONS_SCORE: 0.3206

DSS_SCORE: 0.6521

HELIX: 0.1266

FCONS_SCORE: 0.9686

RIG_SCORE: 0.6665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T106A	SIDM00118	Colorectal Carcinoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	0.6111
p.T106A	ACH-001081	Colon/Colorectal Cancer	CCLE	SKENQ	DEG_APCC_KENBOX_2	0.6111
p.T106A	HCC2998	large_intestine	COSMIC	SKENQ	DEG_APCC_KENBOX_2	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_APCC_KENBOX_2	2601:2605	SKENQ	APC,CDC20,FZR1	0.9747	More...
Q12834	Cell division cycle protein 20 homolog	DEG_APCC_KENBOX_2	96:100	SKENQ	APC,CDC20,FZR1	0.985	More...
Q13683	Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]	DEG_APCC_KENBOX_2	118:122	SKENQ	APC,CDC20,FZR1	0.9673	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons