DegronMD - Q13683(ITGA7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R129W	TCGA-A8-A094	BRCA	TCGA	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.R129W	TCGA-ER-A193	SKCM	TCGA	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.R129W	TCGA-FW-A3R5	SKCM	TCGA	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.R129W	DO2593	BRCA	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.R129W	DO37406	SKCM	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.R129W	DO47368	SKCM	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.E120D	TCGA-CA-6717	COAD	TCGA	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.6758
p.E120D	DO8264	COAD	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.6758
p.D109N	TCGA-DK-A6AW	BLCA	TCGA	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.0833
p.D109N	TCGA-EO-A22R	UCEC	TCGA	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.0833
p.D109N	DO48566	BLCA	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.0833
p.D109N	DO42713	UCEC	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.0833
p.R129L	TCGA-EO-A22X	UCEC	TCGA	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.R129L	DO43907	UCEC	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1389
p.S118C	DO234276	ESAD	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation altering degron motif	0.643
p.E117G	DO234276	ESAD	ICGC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.3056
p.M114V	SIDM01090	Colorectal Carcinoma	GDSC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2222
p.Y114H	SNU-C5	large intestine	COSMIC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.2222
p.E132K	HGC-27	stomach	COSMIC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.0556
p.H113N	FADU	upper aerodigestive tract	COSMIC	SKENQ	DEG_APCC_KENBOX_2	118:122	Mutation rewiring degron network	0.1944

Kaplan plot for ITGA7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ITGA7

UniProt ID: Q13683

Entrez ID: 3679

Protein name: Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ITGA7 in