DegronMD

Uniprot ID: Q12834

Source protein: Cell division cycle protein 20 homolog

Source gene: CDC20

Class: DEG_APCC_TPR_1

Location: 497:499

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 97.6667

COIL: 0.917

CONS_SCORE: 0.6055

DSS_SCORE: 0.8629

HELIX: 0.03

FCONS_SCORE: 1.756

RIG_SCORE: 0.7105

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R499C	DO222837	MELA	ICGC	GIR	DEG_APCC_TPR_1	0.8301
p.R499C	SIDM00217	Colorectal Carcinoma	GDSC	GIR	DEG_APCC_TPR_1	0.8301
p.R499C	ACH-000999	Colon/Colorectal Cancer	CCLE	GIR	DEG_APCC_TPR_1	0.8301
p.R499C	SNU-1040	large_intestine	COSMIC	GIR	DEG_APCC_TPR_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12834	Cell division cycle protein 20 homolog	DEG_APCC_TPR_1	497:499	GIR	APC,CDC20,FZR1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons