DegronMD

Uniprot ID: Q12834

Source protein: Cell division cycle protein 20 homolog

Source gene: CDC20

Class: DEG_SCF_FBW7_1

Location: 56:63

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 90.875

COIL: 0.9575

CONS_SCORE: 0.3715

DSS_SCORE: 0.8495

HELIX: 0.018

FCONS_SCORE: 1.2139

RIG_SCORE: 0.4928

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P71A	TCGA-69-7978	LUAD	TCGA	PGRTPGKS	DEG_SCF_FBW7_1	0.1111
p.P71A	DO24920	LUAD	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	0.1111
p.Q68R	TCGA-75-6214	LUAD	TCGA	PGRTPGKS	DEG_SCF_FBW7_1	0.1944
p.Q68R	DO24830	LUAD	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	0.1944
p.A46S	DO229022	LICA	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	0.0556
p.A46T	DO229221	THCA	ICGC	PGRTPGKS	DEG_SCF_FBW7_1	0.0556
p.G57R	SIDM01136	Pancreatic Carcinoma	GDSC	PGRTPGKS	DEG_SCF_FBW7_1	0.6457
p.G57R	ACH-000417	Pancreatic Cancer	CCLE	PGRTPGKS	DEG_SCF_FBW7_1	0.6457
p.G57R	PANC-08-13	pancreas	COSMIC	PGRTPGKS	DEG_SCF_FBW7_1	0.6457

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12834	Cell division cycle protein 20 homolog	DEG_SCF_FBW7_1	56:63	PGRTPGKS	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons