DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: LIG_APCC_ABBAyCdc20_2

Location: 792:798

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9681

ASA_SCORE: 91.1857

COIL: 0.7776

CONS_SCORE: 0.3605

DSS_SCORE: 0.5218

HELIX: 0.1464

FCONS_SCORE: 1.0471

RIG_SCORE: 0.6912

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H806R	TCGA-12-0827	GBM	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.H806R	DO12538	GBM	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R786C	TCGA-AP-A051	UCEC	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R786C	DO42673	UCEC	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R786H	TCGA-AX-A1CE	UCEC	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R786H	DO233665	GACA	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R786H	DO42280	UCEC	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1667
p.R805Q	TCGA-CA-6717	COAD	TCGA	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.R805Q	DO8264	COAD	ICGC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.1389
p.D807G	SIDM00564	Ovarian Carcinoma	GDSC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D807G	ACH-000527	Ovarian Cancer	CCLE	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D807G	OVISE	ovary	COSMIC	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.0833
p.D807Y	ACH-000975	Lung Cancer	CCLE	KQSLYGD	LIG_APCC_ABBAyCdc20_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	LIG_APCC_ABBAyCdc20_2	792:798	KQSLYGD	APC,CDC20,FZR1	0.9681	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons