DegronMD

Uniprot ID: P25054

Source protein: Adenomatous polyposis coli protein

Source gene: APC

Class: DEG_SCF_FBW7_2

Location: 2150:2155

E3 ligase: FBXW7

DEGRON score: 0.9046

ASA_SCORE: 95.9333

COIL: 0.7363

CONS_SCORE: 0.4031

DSS_SCORE: 0.6111

HELIX: 0.2548

FCONS_SCORE: 0.9698

RIG_SCORE: 0.6683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L2144M	TCGA-05-4396	LUAD	TCGA	LTPDQE	DEG_SCF_FBW7_2	0.1667
p.L2144M	DO23838	LUAD	ICGC	LTPDQE	DEG_SCF_FBW7_2	0.1667
p.Q2154E	TCGA-85-8666	LUSC	TCGA	LTPDQE	DEG_SCF_FBW7_2	0.5633
p.Q2154E	DO45547	LUSC	ICGC	LTPDQE	DEG_SCF_FBW7_2	0.5633
p.G2145R	TCGA-BH-A0HF	BRCA	TCGA	LTPDQE	DEG_SCF_FBW7_2	0.1944
p.G2145R	DO1749	BRCA	ICGC	LTPDQE	DEG_SCF_FBW7_2	0.1944
p.Q2154P	DO232761	PBCA	ICGC	LTPDQE	DEG_SCF_FBW7_2	0.5924
p.G2145V	SIDM00455	Pancreatic Carcinoma	GDSC	LTPDQE	DEG_SCF_FBW7_2	0.1944
p.G2145V	ACH-000599	Pancreatic Cancer	CCLE	LTPDQE	DEG_SCF_FBW7_2	0.1944
p.G2145V	PA-TU-8902	pancreas	COSMIC	LTPDQE	DEG_SCF_FBW7_2	0.1944
p.L2150V	SIDM00927	Small Cell Lung Carcinoma	GDSC	LTPDQE	DEG_SCF_FBW7_2	0.5654
p.L2150V	ACH-000871	Lung Cancer	CCLE	LTPDQE	DEG_SCF_FBW7_2	0.5654
p.L2150V	NCI-H510A	lung	COSMIC	LTPDQE	DEG_SCF_FBW7_2	0.5654

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P25054	Adenomatous polyposis coli protein	DEG_SCF_FBW7_2	2150:2155	LTPDQE	FBXW7	0.9046	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons